Crystal Palace captain Marc Guehi is expected to withdraw from England's squad after picking up an injury in the Europa Conference League on Thursday.
The 25-year-old 'bruised a foot bone' in the dying embers of the Eagles' clash with AZ Alkmaar and hobbled away from Selhurst Park on crutches.
Oliver Glasner ruled him out of Palace's derby against Brighton on Sunday, admitting 'he can't even walk', and now Guehi looks set to pull out of his country's squad for their World Cup Qualifiers against Albania and Serbia.
Chelsea's Trevoh Chalobah, previously managed by Thomas Tuchel at Stamford Bridge, is in line to join up with England as Guehi's replacement.
The 26-year-old was handed his first international call-up in May, making his debut in England's friendly 3-1 defeat to Senegal at the City Ground. He was however later omitted Tuchel's squad for September's qualifiers, with the German admitting he was 'unfortunate' not to have been called up.
Further late additions to the squad for Thursday's game against the Serbians are also expected after Newcastle United boss Eddie Howe revealed Anthony Gordon and Nick Pope will also have to withdraw.
While Gordon was ruled out of the Magpies' trip to Brentford with a hip injury, Pope was forced off during the game in west London after suffering a concussion.
Speaking following his side's 3-1 defeat, Howe said: 'Nick Pope suffered a concussion and that's why we took him off. As soon as were made aware of that, he was withdrawn.
'He won't go with England, it's 12 days recovery, I think. Anthony Gordon has a minor injury, so he'll miss England.'
Tuchel's announcement on Friday saw five players omitted from the squad who beat Wales and Latvia last month.
Myles Lewis-Skelly, Ruben Loftus-Cheek, Morgan Gibbs-White and James Trafford all missed out, as did Aston Villa forward Ollie Watkins.
England's manager said the striker's absence was fitness related, while stressing that the other four lost their places having been 'outperformed' since the last international break.
'Myles was a very good team-mate and played for us in the last camp in the World Cup qualifier in Riga, so was Ruben Loftus-Cheek, so was Morgan Gibbs-White and James Trafford,' Tuchel said.
‘But I said last time there is a component to it that it's about competition and performance and the door is always open for guys who perform on a regular and high level.
‘Myles, Ruben and Morgan got out-performed by Nico O'Reilly, Alex Scott, Nick Pope and Jude in their positions.
‘Myles simply needs more starts, more minutes. Now came a time when Nico O'Reilly had so many starts in that position, so he is slightly ahead for this camp.’
Tuchel meanwhile chose to recall Real Madrid star Jude Bellingham, whose omission from October's squad left waves of English fans shocked.
The 22-year-old was left out as he recovered from a shoulder injury, despite already making his LaLiga return.
Yet Bellingham will feature for England this week alongside Phil Foden, who's also earned a recall.
Tuchel said: 'Jude has the edge which is a very good thing because you need a certain edge to reach the heights that he reached and I think we all need to help him, and to encourage him, or to create an environment that he can live this edge towards the opponent, towards the goals that we are building as a team. That is the main target.
'It is now necessary that we provide an environment and he lives up to this environment, to provide this edge for us in a positive way, and win football games.'
Asked about his decision to drop the duo last month, the boss added: 'I think it was more of a message to the guys who were in camp rather than a message for Jude because there was no need for that, for the guys to keep their place even if a guy like Jude, like Phil, like other big names are knocking on the door and claiming their right to be back which is their right to claim that.
'The message is now, make sure you keep this thing going and make sure you accelerate the thing because we have something going here, we are building something, we are super-excited that you are back but the message is - contribute to it.
'But yeah, there is competition. And the players will know camp by camp where they compete. If you use the example that we bring four number-10s in. Because all four individually deserve to be in camp. And then we have four on the number-10 position but only one left-winger, for example. This does not make sense.'
